Pelizon, A. C. [UNESP]Kaneno, Ramon [UNESP]Soares, A. M V CMeira, D. A.Sartori, A.2014-05-272014-05-272005-11-16Physiological Research, v. 54, n. 5, p. 557-564, 2005.0862-8408http://hdl.handle.net/11449/68495In this study we investigated the effect of β-glucan derived from Saccharomyces cerevisiae on fungicidal activity, cytokine production and natural killer activity. Spleen and peritoneal cells from female C57BL/6 mice, previously injected (24 or 48 h) with 20 or 100 μg of glucan by i.p. route, were assayed. In vivo β-glucan administration primed spleen cells for a higher production of IL-12 and TNF-α when S. aureus was used as a stimulus. In addition, β-glucan increased NK spleen cells activity against YAC target cells. Some immunomodulatory activities not yet described for β-glucan were observed in this work. © 2005 Institute of Physiology, Academy of Sciences of the Czech Republic.557-564engβ-glucanFungicidal activityIL-12NK activityTNF-αbeta glucaninterleukin 12tumor necrosis factor alphaanimal cellanimal experimentcell activitycontrolled studycytokine productiondrug effectfemalefungicidal activityimmunomodulationmousenatural killer cellnonhumanperitoneum cellSaccharomyces cerevisiaespleen celltarget cellAnimalsAntifungal Agentsbeta-GlucansCytokinesDose-Response Relationship, DrugFemaleImmunologic FactorsKiller Cells, NaturalMiceMice, Inbred C57BLParacoccidioidesArtigoAcesso aberto2-s2.0-276445255842-s2.0-27644525584.pdf884583555063780949775724161295270000-0002-4292-3298