Viero, Rosa Marlene [UNESP]Soares, Vitor A. [UNESP]2014-05-272014-05-271998-08-13Renal Failure, v. 20, n. 4, p. 565-571, 1998.0886-022Xhttp://hdl.handle.net/11449/65495Rats treated with two injections of adriamycin (week 0 and week 12) developed glomerusclerosis and severe tubulointerstitial lesions as described in the literature. In addition, a number of glomerular alterations were present. These included capillary loop dilation, insudation of eosinophilic material, necrosis, duplication of the glomerular basement membrane, severe mesangiolysis with disruption of the mesangial matrix and segmental double- contours. The renal arterioles and interlobular arteries showed endothelial cell swelling. The subendothelial space was infiltrated by fibrinoid material and there was intensive fibrinoid necrosis of the wall of both arteries and arterioles extending into the glomerular tuft. These alterations were very similar to those observed in the hemolytic uremic syndrome. This observation suggests that the two injections of adriamycin, with a long interval in between them, might induce renal lesions similar to those observed in the hemolytic uremic syndrome.565-571engAdriamycinHemolytic uremic syndromedoxorubicinhydroxyprolineserum albuminsodium chlorideanimal experimentanimal modelanimal tissuecontrolled studycreatinine clearanceglomerulosclerosisglomerulus basement membraneglomerulus capillaryhemolytic uremic syndromeinterstitial nephritiskidney arterykidney diseasemalemesangiumnonhumanpriority journalratAnimalsAntineoplastic AgentsDoxorubicinGlomerulonephritisHemolytic-Uremic SyndromeKidney GlomerulusMaleNephritis, InterstitialRatsRats, WistarTime FactorsArtigo10.3109/08860229809045148Acesso restrito2-s2.0-00318538101453564171333848