Santos, G. C.Zucoloto, S.Coelho, Kunie Iabuki Rabello [UNESP]Schmitt, F. C.2014-05-272014-05-271992-04-01Arquivos de Gastroenterologia, v. 29, n. 2, p. 62-65, 1992.0004-2803http://hdl.handle.net/11449/64230A tubular adenocarcinoma of the colon with solid area composed by small cells that was found by immunohistochemistry study using antibody to neuron-specific enolase (NSE) to possess neuroendocrine differentiation is related. In another areas of the tumor were visualized keratinizing squamous cells. The presence of neuro-endocrine and squamous cells features provide further evidence that neoplastic colonic cells have the capacity for multi-directional differentiation. The implications of this combination in relation to theories of tumor origin and differentiation and the prognostic significance of neuro-endocrine cells in malignant neoplasms of the gastrointestinal tract are discussed.62-65poradenocarcinomaagedcase reportcell differentiationcolon tumorfemalehumanimmunohistochemistryneurosecretionpathologysquamous cell carcinomaAdenocarcinomaAgedCarcinoma, Squamous CellCase ReportCell DifferentiationColonic NeoplasmsEnglish AbstractFemaleHumanImmunohistochemistryNeurosecretory SystemsArtigoAcesso restrito2-s2.0-0026849368