Miyahara, Glauco Issamu [UNESP]Simonato, Luciana Estevam [UNESP]Mattar, Neivio José [UNESP]Camilo Jr, Deolino João [UNESP]Biasoli, Eder Ricardo [UNESP]2013-09-302014-05-202013-09-302014-05-202011-03-01Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 106, n. 2, p. 166-169, 2011.0074-0276http://hdl.handle.net/11449/15625The purpose of this study was to compare the histopathological analysis with polymerase chain reaction (PCR) methods to predict the presence of human papillomavirus (HPV) infection in oral squamous cell carcinoma biopsies. Eighty-three paraffin-embedded tissue specimens from patients with oropharynx and mouth floor squamous cell carcinoma were submitted to histopathological analysis under light microscopy, specifically for the determination of the presence of koilocytes. Subsequently, DNA was purified from the same paraffin-embedded specimens and submitted to PCR. Fisher's exact test showed no statistically significant correlation between the two methods. The results suggest that the presence of koilocytes is unreliable for the detection of HPV presence in oral and oropharynx squamous cell carcinoma.166-169enghuman papillomavirussquamous cell carcinomamicroscopypolymerase chain reactionArtigo10.1590/S0074-02762011000200008S0074-02762011000200008WOS:000289961100008Acesso abertoS0074-02762011000200008.pdf38468911670832110000-0002-5326-2026