Gelaleti, Rafael Bottaro [UNESP]Damasceno, Débora C. [UNESP]Santos, Daniele P.Calderon, Iracema M P [UNESP]Rudge, Marilza Vieira Cunha [UNESP]2015-12-072015-12-072015-09-02Reproductive Sciences (thousand Oaks, Calif.), p. 771–775, 2015.1933-7205http://hdl.handle.net/11449/131555This study aimed at correlating maternal blood glucose levels with DNA damage levels in the offspring of women with diabetes or mild gestational hyperglycemia (MGH). Based on oral glucose tolerance test results and glycemic profiles, 56 pregnant women were allocated into 3 groups: nondiabetes, MGH, and diabetes. The offspring of these women (56 infants) were also evaluated. Maternal peripheral blood and umbilical cord blood samples were collected and processed for biochemical and DNA damage analysis by the comet assay. A positive correlation between maternal blood glucose mean and increased offspring DNA damage levels was observed. Hyperglycemia played a role in offspring DNA damage, but other diabetes-induced complications were also involved. Increased maternal blood glucose levels can lead to increased offspring DNA damage levels. Therefore, the monitoring, control, and treatment of pregnant women with diabetes and MGH are highly important to ensure a risk-free pregnancy and healthy infants.771–775engDna damageDiabetesMild gestational hyperglycemiaNewbornsPregnant womenArtigo10.1177/1933719115602766Acesso restrito6758680388835078263351780000-0002-9227-832X