Longhini-dos-Santos, NathaliaBarbosa-de-Oliveira, Valter AbraãoKozma, Rodrigo Herasde Faria, Carolina ArrudaStessuk, TalitaFrei, Fernando [UNESP]Ribeiro-Paes, João Tadeu [UNESP]2014-05-272014-05-272013-01-01Stem Cell Reviews and Reports, v. 9, n. 2, p. 210-218, 2013.1550-89431558-6804http://hdl.handle.net/11449/74151Emphysema is characterized by destruction of alveolar walls with loss of gas exchange surface and consequent progressive dyspnea. This study aimed to evaluate the efficiency of cell therapy with bone marrow mononuclear cells (BMMC) in an animal model of elastase-induced pulmonary emphysema. Emphysema was induced in C57Bl/J6 female mice by intranasal instillation of elastase. After 21 days, the mice received bone marrow mononuclear cells from EGFP male mice with C57Bl/J6 background. The groups were assessed by comparison and statistically significant differences (p & 0. 05) were observed among the groups treated with BMMC and evaluated after 7, 14 and 21 days. Analysis of the mean linear intercept (Lm) values for the different groups allowed to observe that the group treated with BMMC and evaluated after 21 days showed the most significant result. The group that received no treatment showed a statistically significant difference when compared to other groups, except the group treated and evaluated after 21 days, evidencing the efficacy of cell therapy with BMMC in pulmonary emphysema. © 2012 Springer Science+Business Media New York.210-218engAnimal modelCell therapyCOPDPulmonary emphysemaStem cellsbiological markerpancreatic elastaseanimalbone marrow cellbone marrow transplantationC57BL mousechemically induced disorderchemistrycytologyfemalehumanimmunologyimmunophenotypinglunglung emphysemalung lavagemalemetabolismmononuclear cellmousepathologytransgenic mousetransplantationAnimalsBiological MarkersBone Marrow CellsBone Marrow TransplantationBronchoalveolar Lavage FluidFemaleHumansImmunophenotypingLeukocytes, MononuclearLungMaleMiceMice, Inbred C57BLMice, TransgenicPancreatic ElastasePulmonary EmphysemaAnimaliaMusArtigo10.1007/s12015-012-9419-yWOS:000317074300011Acesso restrito2-s2.0-848756232814165274708509804