Coronado, Monika A. [UNESP]Georgieva, DessislavaBuck, FriedrichGabdoulkhakov, Azat H.Ullah, Anwar [UNESP]Spencer, Patrick J.Arni, Raghuvir K. [UNESP]Betzel, Christian2014-05-202014-05-202012-09-01Acta Crystallographica Section F-structural Biology and Crystallization Communications. Hoboken: Wiley-blackwell, v. 68, p. 1052-1054, 2012.1744-3091http://hdl.handle.net/11449/22104Crotamine, a highly basic myotoxic polypeptide (molecular mass 4881 Da) isolated from the venom of the Brazilian rattlesnake Crotalus durissus terrificus, causes skeletal muscle contraction and spasms, affects the functioning of voltage-sensitive sodium channels by inducing sodium influx and possesses antitumour activity, suggesting potential pharmaceutical applications. Crotamine was purified from C. durissus terrificus venom; the crystals diffracted to 1.9 angstrom resolution and belonged to the orthorhombic space group I212121 or I222, with unit-cell parameters a = 67.75, b = 74.4, c = 81.01 angstrom. The self-rotation function indicated that the asymmetric unit contained three molecules. However, structure determination by molecular replacement using NMR-determined coordinates was unsuccessful and a search for potential derivatives has been initiated.1052-1054engcrotaminemyotoxinsCrotalus durissus terrificusArtigo10.1107/S1744309112032721WOS:000308407200011Acesso restritoWOS000308407200011.pdf91625089789458870000-0003-2460-1145