Medina, Rebeca P.Araujo, Angela R.Andersen, Raymond J.Soares, Marcos A.Silva, Fabio de A.Silva, Dulce H. S.2018-12-112018-12-112018-03-25Natural Product Research, p. 1-4.1478-64271478-6419http://hdl.handle.net/11449/177113Endophytic fungi were isolated from red alga Asparagopsis taxiformis - Falkenbergia stage, collected from the Brazilian coast, and were identified as Annulohypoxylon stygium (AT-03) and A. yungensis (AT-06) based on their macro/micromorphological and molecular features. Bioassay-guided fractionation of the EtOAc extract from laboratory cultures of both strains yielded known compounds pyrogallol from A. stygium, (3R)-scytalone and (3R,4R)-4-hydroxy-scytalone from A. yungensis. Pyrogallol was active against methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli strains. An inactive fraction from A. stygium afforded two additional compounds, (3R,4R)-3,4,5-trihydroxy-1-tetralone and tyrosol. Optically active compounds had their stereochemistry determined by circular dichroism (CD) spectroscopy.1-4engAnnulohypoxylonantimicrobial activityaromatic compoundsAsparagopsis taxiformisendophytic fungusMarine red algaArtigo10.1080/14786419.2018.1455037Acesso aberto2-s2.0-850444479692-s2.0-85044447969.pdf47020049042312480000-0002-1516-7765