Bartchewsky, WaldemarMartini, Mariana R.Squassoni, Aline C.Alvarez, Marisa C.Ladeira, Marcelo S. P. [UNESP]Salvadori, Daisy Maria Favero [UNESP]Trevisan, Miriam A.Pedrazzoli, JoseRibeiro, Marcelo L.2014-05-202014-05-202010-01-01Digestive Diseases and Sciences. Dordrecht: Springer, v. 55, n. 1, p. 111-116, 2010.0163-2116http://hdl.handle.net/11449/11410The aim of the present study is to evaluate the influence of Helicobacter pylori on Bax and Bcl-2 mRNA and protein levels in patients with chronic gastritis and gastric cancer. The study included 217 patients, of which 26 were uninfected; 127 had chronic gastritis and were H. pylori-positive, and 64 had gastric cancer. Bacterial genotypes were evaluated by PCR, and the expression values were determined by quantitative real-time PCR and immunohistochemistry. Our data showed that the up-regulationary effects of H. pylori infection on the proapoptotic gene, Bax, were stronger than its induction of Bcl-2; this effect may increase apoptosis in patients with chronic gastritis. In patients with gastric cancer, the up-regulation of the anti-apoptotic gene, Bcl-2, counteracted the pro-apoptotic effects of Bax, leading to a deregulation of apoptosis-associated gene expression, favoring cell proliferation. Thus, the disturbance in Bax and Bcl-2 balance, induced by H. pylori, might be important in gastric cancer development.111-116engHelicobacter pyloriGastric cancerBaxBcl-2Real-time PCRArtigo10.1007/s10620-008-0699-7WOS:000273520500018Acesso restrito5051118752980903