Torres, Sandra R.Chen, Curtis S. K.Leroux, Brian G.Lee, Peggy P.Hollender, Lars G.Santos, Eduardo C. A. [UNESP]Drew, Shane P.Hung, Kuei-ChingSchubert, Mark M.2014-05-202014-05-202012-05-01Oral Surgery Oral Medicine Oral Pathology Oral Radiology. New York: Elsevier B.V., v. 113, n. 5, p. 695-703, 2012.2212-4403http://hdl.handle.net/11449/42641Objectives. The objective of this study was to develop a technique for detecting cortical bone dimensional changes in patients with bisphosphonate-related osteonecrosis of the jaw (BRONJ).Study Design. Subjects with BRONJ who had cone-beam computed tomography imaging were selected, with age- and gender-matched controls. Mandibular cortical bone measurements to detect bisphosphonate-related cortical bone changes were made inferior to mental foramen, in 3 different ways: within a fixed sized rectangle, in a rectangle varying with the cortical height, and a ratio between area and height.Results. Twelve BRONJ cases and 66 controls were evaluated. The cortical bone measurements were significantly higher in cases than controls for all 3 techniques. The bone measurements were strongly associated with BRONJ case status (odds ratio 3.36-7.84). The inter-rater reliability coefficients were high for all techniques (0.71-0.90).Conclusions. Mandibular cortical bone measurement is a potentially useful tool in the detection of bone dimensional changes caused by bisphosphonates. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:695-703)695-703engArtigo10.1016/j.oooo.2011.11.011WOS:000303402200027Acesso abertoWOS000303402200027.pdf