García, Fernando Antonio Vázquez [UNESP]Otarola, Wilfredo Gustavo Escalante [UNESP]Keine, Katia Cristina [UNESP]García, Arturo Javier Aranda [UNESP]Kuga, Gabriel Keine [UNESP]Kuga, Milton Carlos [UNESP]2021-06-252021-06-252020-01-01Revista Cubana de Farmacia, v. 53, n. 4, p. 1-26, 2020.1561-29880034-7515http://hdl.handle.net/11449/208404Introduction: Endodontic complications, such as the presence of inflammation, pain, infection and anesthetic difficulties, require rationalization in systemic drug therapy. Objective: To describe the indications, contraindications and side effects of prescribing and using medications in the main clinical situations before, during and after root canal treatment. Methods: A compilation of bibliographic references was made after a search carried out in using the PubMed search engine, which has free access to MEDLINE. The following keywords were used: medicación sistémica endodóntica [endodontic systemic medication], pulpitis irreversible sintomática [symptomatic irreversible pulpitis]; periodontitis apical sintomática [symptomatic apical periodontitis], and absceso apical agudo [acute apical abscess]. We retrieved 274 articles, of which 68 were considered relevant, since they contemplated the solving of endodontic problems. Conclusions: The elaboration of protocols about the fundamentals of scientific research and based upon clinical evidence allows treating root canals with safety and well-being for the patient, thus increasing clinical success rates.1-26spaAcute apical abscessEndodontic systemic medicationSymptomatic apical periodontitisSymptomatic irreversible pulpitisArtigo2-s2.0-85100808265