Silva, Geraldo HumbertoTeles, Helder LopesZanardi, Lisineia MariaMarx Young, Maria ClaudiaEberlin, Marcos NogueiraHadad, RenatoPfenning, Ludwig H.Costa-Neto, Claudio MiguelCastro-Gamboa, IanBolzani, Vanderlan da Silva [UNESP]Araujo, Angela Regina2014-05-202014-05-202006-09-01Phytochemistry. Oxford: Pergamon-Elsevier B.V., v. 67, n. 17, p. 1964-1969, 2006.0031-9422http://hdl.handle.net/11449/32274Five cadinane sesquiterpenes derivatives were isolated by bioassay-guided fractionation from Phomopis cassiae, an endophytic fungus isolated from Cassia spectabilis. The structures of the two diastereoisomeric 3,9,12-trihydroxycalamenenes (1, 2); 3,12-dihydroxycalamenene (3); 3,12-dihydroxycadalene (4) and 3,11,12-trihydroxycadalene (5) were established on the basis of analyses of ID and 2D NMR and HRTOFMS experiments. Antifungal activity of the isolates was evaluated against Cladosporium sphaerospermum and Cladosporium cladosporioides, revealing 5 as the most active compound. (c) 2006 Elsevier Ltd. All rights reserved.1964-1969engPhomopsisendophytic fungiCadinane SesquiterpenesantifungalArtigo10.1016/j.phytochem.2006.06.004WOS:000240821700013Acesso restrito0000-0001-7616-9652