Sa-Nunes, A.Faccioli, L. H.Sforcin, J. M.2014-05-202014-05-202003-07-01Journal of Ethnopharmacology. Clare: Elsevier Sci Ireland Ltd, v. 87, n. 1, p. 93-97, 2003.0378-8741http://hdl.handle.net/11449/18047We evaluated propolis influence on polyclonal activation of lymphocytes by concanavalin A (Con A). The in vitro experiments showed that propolis decreases splenocyte proliferation both in the absence or presence of Con A. The supression in mitogen-induced splenocyte proliferation also occurred when mice were treated intraperitoneally with propolis for 3 days. An increased of IFN-gamma production in the culture supernatants of the same cells was, observed. A dual action of propolis on lymphocyte activation was proposed: it decreases splenocyte proliferation in the presence or absence of Con A and stimulates IFN-gamma production by spleen cells. These results are important to understand the immunomodulatory action of propolis on the host's specific and non-specific immunity. (C) 2003 Elsevier B.V. Ireland Ltd. All rights reserved.93-97engpropolismitogen-induced proliferationIFN-gammalymphocyte activationArtigo10.1016/S0378-8741(03)00121-1WOS:000183590200015Acesso restrito