Shibli, Jamil AwadPiattelli, AdrianoIezzi, GiovannaCardoso, Luciana Ap.Onuma, TatianaPerri de Carvalho, Paulo Sergio [UNESP]d'Avila, SusanaFerrari, Daniel S.Mangano, CarloZenobio, Elton Goncalves2013-09-302014-05-202013-09-302014-05-202010-04-01Journal of Periodontology. Chicago: Amer Acad Periodontology, v. 81, n. 4, p. 575-583, 2010.0022-3492http://hdl.handle.net/11449/15653Background: This prospective and controlled histologic study evaluates the impact of smoking on bone-to-implant contact, the bone density in the threaded area, and the bone density outside the threaded area around microimplants with anodized surface retrieved from human jaws.Methods: A total of 24 subjects (mean age 51.32 +/- 7.5 years) were divided in two groups: smokers (n = 13 subjects) and non-smokers (n = 11 subjects). Each subject received one microimplant with oxidized surface during conventional mandible or maxilla implant surgery. After 8 weeks, the microimplants and the surrounding tissue were removed and prepared for histomorphometric analysis.Results: Three microimplants placed in smokers showed no osseointegration. The newly formed bone showed early stages of maturation, mainly in the non-smokers. Marginal bone loss, gap, and fibrous tissue were present around implants retrieved from smokers. Histometric evaluation indicated that the mean bone-to-implant contact ranged between 25.97% +/- 9.02% and 40.01% +/- 12.98% for smokers and non-smokers, respectively (P <0.001). Smokers presented 28.17% +/- 10.32% of bone density in the threaded area, whereas non-smokers showed 46.34% +/- 19.12%. The mean of bone density outside the threaded area ranged between 18.76% and 25.11% for smokers and non-smokers, respectively (P>0.05).Conclusion: The present data obtained in human subjects confirm that smoking has a detrimental effect on early bone tissue response around oxidized implant surfaces. J Periodontol 2010;81:575-583.575-583engDental implantshistologyosseointegrationsmokingwound healingArtigo10.1902/jop.2010.090493WOS:000283020800016Acesso restrito