Salgado, Paula Fialho SaraivaSabbag, Amália TiecoDa Silva, Priscila CostaBrienze, Sergio Luís AparecidoDalto, Helio PontesMódolo, Norma Sueli Pinheiro [UNESP]Braz, José Reinaldo Cerqueira [UNESP]Nascimento Junior, Paulo do [UNESP]2014-05-272014-05-272008-03-01Revista da Associacao Medica Brasileira, v. 54, n. 2, p. 110-115, 2008.0104-4230http://hdl.handle.net/11449/70329BACKGROUND. This study aimed to evaluate clinical characteristics of epidural anesthesia performed with 0.75% ropivacaine associated with dexmedetomidine. METHODS. Forty patients scheduled for hernia repair or varicose vein surgeries under epidural anesthesia participated in this study. They were assigned to: Control Group (n = 20), 0.75% ropivacaine, 20 ml (150 mg); and Dexmedetomidine Group (n = 20), 0.75% ropivacaine, 20 ml (150 mg), plus dexmedetomidine, 1 μg.kg -1. The following variables were studied: total analgesic block onset time, upper level of analgesia, analgesic and motor block duration time, intensity of motor block, state of consciousness, hemodynamics, postoperative analgesia and incidence of side-effects. RESULTS. Epidural dexmedetomidine did not affect onset time or upper level of anesthesia (p > 0.05) however it prolonged sensory and motor block duration time (p < 0.05) and postoperative analgesia (p < 0.05), and also resulted in a more intense motor block, 1 (p < 0.05). Values of bispectral index were lower in Dexmedetomidine Group (p < 0.05). There was no difference in incidence of hypotension and bradycardia (p > 0.05). Occurrence of side-effects (shivering, vomiting and SpO 2 < 90%) was low and similar between groups (p > 0.05). CONCLUSION. There is clear synergism between epidural dexmedetomidine and ropivacaine, further this drug association does not bring about additional morbidity.110-115porAnalgesicsAnesthetic techniquesAnestheticsDexmedetomidineEpidural blockRopivacainealpha adrenergic receptor stimulating agentamidedexmedetomidinelocal anesthetic agentropivacaineadolescentadultchi square distributionclinical trialcontrolled clinical trialcontrolled studydouble blind proceduredrug potentiationepidural anesthesiafemalehumaninguinal hernialegmalemiddle agednerve blocknonparametric testrandomized controlled trialtimeAdolescentAdrenergic alpha-AgonistsAdultAmidesAnesthesia, EpiduralAnesthetics, LocalChi-Square DistributionDouble-Blind MethodDrug SynergismFemaleHernia, InguinalHumansLower ExtremityMaleMiddle AgedNerve BlockStatistics, NonparametricTime FactorsYoung AdultArtigo10.1590/S0104-42302008000200011S0104-42302008000200011Acesso aberto2-s2.0-458490960582-s2.0-45849096058.pdf822354647572405887453589896806000000-0002-2323-9159