Drimel Molina, FernandoGolloni-Bertollo, Eny MariaTaboga, Sebastião Roberto [UNESP]Maniglia, José Victor2014-05-272014-05-272003-06-01Revista Brasileira de Medicina, v. 60, n. 6, p. 365-370, 2003.0034-7264http://hdl.handle.net/11449/67313This paper intend to review recent advances in our understanding of programmed cell death, or apoptosis, and discuss implications of these basic science advances in the development of causes and potential treatments of a variety of diseases of the head and neck. Conclusions: apoptosis is now understood to be important in the normal development and survival of all multicellular organism. Deregulation of this normally tighly controlled process underlies a variety of disease states, including neoplasia, autoimmune disease, and disorders of the central nervous system. A better understanding of this process and regulation may help otolaryngologists better understand diseases relevant to this specialty and will lead to improved therapeutic interventions.365-370porApoptosisCancerHead and neck tumorsOtorhinolaringologyProgramed cell deathFas antigenprotein BADprotein Baxprotein bcl 2protein bcl xprotein bcl xlprotein p53AdenovirusAlzheimer diseaseaplastic anemiaapoptosisautoimmune diseasebreast adenomacarcinogenesiscell activitycell functioncell proliferationcell structurecell survivalcentral nervous systemfollicular lymphomaglomerulonephritisHerpes virusHerpes virus infectionhormone dependencehumanischemialiver diseasemedical specialistmolecular dynamicsneoplasmnonhumanolfactory nerve diseaseotorhinolaryngologyovary tumorParkinson diseasePoxvirusPoxvirus infectionprostate carcinomaprotein analysisprotein determinationprotein functionreviewsystemic lupus erythematosusvestibular disordervirus infectionArtigoAcesso aberto2-s2.0-004263110814452594685261880000-0002-0970-4288