Saad, W. A.Luiz, A. C.Camargo, LAAMenani, José Vanderlei [UNESP]Renzi, Antonio [UNESP]Silveira, JEN2014-05-202014-05-201993-09-01Brazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 26, n. 9, p. 999-1007, 1993.0100-879Xhttp://hdl.handle.net/11449/314771. The effect of lisinopril, a potent inhibitor of angiotensin converting enzyme (ACE), injected into the medial preoptic area (MPOA) on water intake was investigated in male Holtzman rats (200-250 g).2. Injection of lisinopril (2 mug/mul) into the MPOA abolished the water intake induced by subcutaneous (sc) injection of isoprenaline (100%) and water deprivation (90%) and drastically reduced the water intake induced by sc injection of polyethyleneglycol (60%). A small reduction of water intake induced by lisinopril was also observed 90 and 120 min after sc hypertonic saline (N = 10 for each group).3. These results suggest that central ACE activation, particularly in the MPOA, plays an important role in the dipsogenic responses induced by the agents studied.999-1007engWATER INTAKEDEHYDRATIONHYPOVOLEMIAANGIOTENSIN-IILISINOPRILMEDIAL PREOPTIC AREAArtigoWOS:A1993LY94100012Acesso restrito10235978701181056551236936295697