Baldoqui, D. C.Kato, M. J.Cavalheiro, Alberto José [UNESP]Bolzani, Vanderlan da Silva [UNESP]Young, MCMFurlan, Maysa [UNESP]2014-05-202014-05-201999-08-01Phytochemistry. Oxford: Pergamon-Elsevier B.V., v. 51, n. 7, p. 899-902, 1999.0031-9422http://hdl.handle.net/11449/31067In addition to nerolidol, 2',6'-dihydroxy-4'-methoxydihydrochalcone, methyl 2,2-dimethyl-8-(3'-methyl-2'-butenyl)-2H-1-chromene-6-carboxylate, methyl 2,2-dimethyl-2H-1-chromene-6-carboxylate and methyl 8-hydroxy-2,2-dimethyl-2H-1-chromene-6-carboxylate, two new natural products were isolated from the leaves of Piper aduncum, 2,2-dimethyl-2H-1-chromene-6-carboxylic acid and 3-(3',7'-dimethyl-2',6 '-octadienyl)-4-methoxybenzoic acid. The structures of the isolates were established based on analysis of spectroscopic data, including ES-MS. The DNA-damaging activity of the isolated compounds was also investigated against mutant strains of Saccharomyces cerevisiae. (C) 1999 Elsevier B.V. Ltd. All rights reserved.899-902engPiper aduncumPiperaceaechromenesprenylated benzoic aciddihydrochalconenerolidolDNA-damaging activityArtigo10.1016/S0031-9422(99)00132-6WOS:000081437800009Acesso restrito251800682076412044840836852516731308042794786872