Carli, Camila Bernardes de AndradeQuilles, Marcela BassiVilegas, Wagner [UNESP]Carlos, Iracilda Zeppone [UNESP]2016-01-282016-01-282013Journal of Applied Pharmaceutical Science, v. 3, n. 9, p. 8-13, 2013.2231-3354http://hdl.handle.net/11449/133707Species of the genus Qualea are used by the Brazilian public as a natural anti-inflammatory. Based on this evidence, we evaluated the effects of terpene fractions (βF and TF) obtained from Qualea multiflora on nitric oxide production (Griess assay), cytokines (IL-1, IL-10, IL-12, and TNF-a) and the transcription factor NF-κB by peritoneal macrophages. Since there is a relationship between inflammation and cancer, the cytotoxicity of βF and TF against mammary tumoural cell lineage, and macrophages was evaluated. Inhibition levels close to 90% of the production of NO, IL-1, IL-12 and TNF-a; about 32% of NF-κB; and a large stimulation of IL-10 production (close to the positive control) by peritoneal macrophages were observed in response to βF and TF which are correlated with anti-inflammatory activity. Additionally, the samples showed exceptional cytotoxic activity against tumoural cells but not against macrophages. Since anti-inflammatory activity is important in tumour inhibition, further examination of potential anti-cancerous activity of Qualea multiflora is warranted.8-13engArtigoAcesso restrito1730146818754269792787722432683724756078535805490000-0003-3032-2556