Felippe, Lidiane G. [UNESP]Batista, Joao M. [UNESP]Baldoqui, Debora Cristina [UNESP]Nascimento, Isabele Rodrigues [UNESP]Kato, Massuo J.Bolzani, Vanderlan da Silva [UNESP]Furlan, Maysa [UNESP]2014-05-202014-05-202011-09-01Phytochemistry Letters. Amsterdam: Elsevier B.V., v. 4, n. 3, p. 245-249, 2011.1874-3900http://hdl.handle.net/11449/26068A secolignan, (-)-2-methyl-3-[bis(3 ',4 '-methylenedioxy-5 '-methoxyphenyl) methyl] butyrolactone (1), with a rare cis configuration was isolated from the aerial parts of Peperomia blanda (Piperaceae). The structure of this compound was elucidated by a combination of spectroscopic methods, including ultraviolet, infrared, 1D- and 2D- nuclear magnetic resonance as well as high resolution mass spectrometry data. The absolute configuration of (-)-1 was determined as (2R,3S) by the comparison of experimental electronic circular dichroism (ECD) spectroscopy and time-dependent density functional theory (TDDFT) calculations. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.245-249engPeperomia blandaPiperaceaeSecolignanAbsolute configurationElectronic circular dichroismDensity functional theoryArtigo10.1016/j.phytol.2011.04.007WOS:000296534500009Acesso restrito012421107179002144840836852516731308042794786872