de Oliveira, Patricia Rosa [UNESP]Bechara, Gervasio Henrique [UNESP]Camargo-Mathias, Maria Izabel [UNESP]2014-05-202014-05-202008-07-01Food and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 46, n. 7, p. 2459-2465, 2008.0278-6915http://hdl.handle.net/11449/19705The ovary of the Rhipicephalus sanguineus dog tick female is structurally formed by oocytes in five different stages of development (from I to V) and attached to the gonad by the pedicel. The present study evaluated possible toxic effects of the acaricide fipronil (Frontline (R)) on ovaries of semi-engorged ticks. Sixty partially fed females of R. sanguineus tick were distributed into four groups of 15 specimens each: I - non-treated; II, III and IV - treated with 1, 5 and 10 ppm of fipronil, respectively. The acaricide induced structural changes in the oocytes of individuals of the different treated groups ranging from the presence of a few small vacuoles to cellular death. In conclusion, germinative cells of semi-engorged R. sanguineus tick female are affected by different concentrations of fipronil leading to the reduction of tick fertility. (c) 2008 Elsevier Ltd. All rights reserved.2459-2465engRhipicephalus sanguineusFipronilOvaryAcaricideCytotoxicityReproductionArtigo10.1016/j.fct.2008.03.034WOS:000257480200024Acesso restrito