Carvalho, Tatiana D. [UNESP]Pastre, Carlos Marcelo [UNESP]de Godoy, Moacir FernandesFereira, CelsoPitta, Fabio O. [UNESP]de Abreu, Luiz CarlosCipulo Ramos, Ercy Mara [UNESP]Valenti, Vitor E.Marques Vanderlei, Luiz Carlos [UNESP]2014-05-202014-05-202011-01-01International Journal of Chronic Obstructive Pulmonary Disease. Albany: Dove Medical Press Ltd, v. 6, p. 23-28, 2011.1176-9106http://hdl.handle.net/11449/7063Background: It was reported that autonomic nervous system function is altered in subjects with chronic obstructive pulmonary disease (COPD). We evaluated short-and long-term fractal exponents of heart rate variability (HRV) in COPD subjects.Patients and methods: We analyzed data from 30 volunteers, who were divided into two groups according to spirometric values: COPD (n = 15) and control (n = 15). For analysis of HRV indices, HRV was recorded beat by beat with the volunteers in the supine position for 30 minutes. We analyzed the linear indices in the time (SDNN [standard deviation of normal to normal] and RMSSD [root-mean square of differences]) and frequency domains (low frequency [LF], high frequency [HF], and LF/HF), and the short-and long-term fractal exponents were obtained by detrended fluctuation analysis. We considered P < 0.05 to be a significant difference.Results: COPD patients presented reduced levels of all linear exponents and decreased short-term fractal exponent (alpha-1: 0.899 +/- 0.18 versus 1.025 +/- 0.09, P = 0.026). There was no significant difference between COPD and control groups in alpha-2 and alpha-1/alpha-2 ratio.Conclusion: COPD subjects present reduced short-term fractal correlation properties of HRV, which indicates that this index can be used for risk stratification, assessment of systemic disease manifestations, and therapeutic procedures to monitor those patients.23-28engpulmonary diseasechronic obstructiveheart ratenervous systemcardiologyArtigo10.2147/COPD.S15099WOS:000208709800003Acesso abertoWOS000208709800003.pdf276139654405860698010612581495635860525135106995