Prezotti, Fabiola Garavello [UNESP]Meneguin, Andreia Bagliotti [UNESP]Evangelista, Raul Cesar [UNESP]Cury, Beatriz Stringhetti Ferreira [UNESP]2014-05-202014-05-202012-11-01Drug Development and Industrial Pharmacy. London: Informa Healthcare, v. 38, n. 11, p. 1354-1359, 2012.0363-9045http://hdl.handle.net/11449/7819High amylose and pectin were mixed at 1: 1 mass ratio and cross-linked with sodium trimetaphosphate (STMP) in alkaline medium. Films were prepared from aqueous dispersions of these cross-linked polymer blend at three different concentrations (3, 4 and 5%), by solvent casting method. Characterization of the films included thickness, surface morphology, water uptake, water vapor permeability (WVP), tensile strength measurements and enzymatic digestion. The cross-linking allowed to obtain films with improved mechanical properties and reduced WVP. The high resistance to enzymatic digestion exhibited by these films represents a promising approach to their application in the development of colon drug delivery systems.1354-1359engThicknesswater uptakewater vapor permeabilitymechanical propertiescontrolled releasecolonArtigo10.3109/03639045.2011.650863WOS:000309453100009Acesso restrito5361569184579557