Braga, AntonioHartmann Uberti, Elza MariaFajardo, Maria do CarmoViggiano, MauricioSun, Sue YazakiGrillo, Bruno MaurizioPadilha, Sergio LunardonAndrade, Jurandyr Moreira deSouza, Christiani Bisinoto deMadi, Jose MauroMaestá, Izildinha [UNESP]Silveira, Eduardo2014-12-032014-12-032014-05-01Journal of Reproductive Medicine. St Louis: Sci Printers & Publ Inc, v. 59, n. 5-6, p. 241-247, 2014.0024-7758http://hdl.handle.net/11449/112136OBJECTIVE: To evaluate treatment of Brazilian patients with gestational trophoblastic disease (GTD).STUDY DESIGN: A retrospective cohort study with analysis of medical reports performed in 10 Brazilian referral centers from January 2000 to December 2011.RESULTS: Of 5,250 patients 3 died (0.06%) at the time of uterine evacuation. Spontaneous remission of GTD (group G1) was observed in 4,103 cases, and 1,144 (21.8%) progressed to gestational trophoblastic neoplasia (GTN) (G2). In G1 2,716 (66.2%) had complete hydatidiform mole (HM) and 1,210, partial HM (29.5%); 3,772 patients (92.7%) recovered as noted in December 2012. In G2, of 1,118 patients treated, initial histopathological results of previous gestation were complete HM (77.5% [n = 886]), partial HM (8.8% [n = 100]), and choriocarcinoma (8.0% [n = 92]); 930 (81.3%) were low-risk, 200 (17.5%) were high-risk GTN, and 14 had placental site trophoblastic tumor (PSTT) (1.2%); cure was achieved in 1,078 cases (96.4%), but 26 patients (2.3%) died (4 low-risk [0.4%], 19 high-risk [9.5%], and 3 PSTT [21.4%]).CONCLUSION: The highest death rates were due to high-risk GTN and PSTT. Patients with molar pregnancy should be referred to a referral center for an early diagnosis and prompt treatment of GTN in order to reduce the morbidity and mortality found in advanced stages.241-247engepidemiologygestational trophoblastic diseasegestational trophoblastic neoplasiahydatidiform moleplacental site trophoblastic tumorArtigoWOS:000336419500012Acesso restrito9012667997804219