Oliveira, Anselmo Gomes de [UNESP]Scarpa, M. V. [UNESP]2014-05-272014-05-271999-12-01Revista de Ciencias Farmaceuticas, v. 20, n. 1, p. 35-47, 1999.0101-3793http://hdl.handle.net/11449/66022A critical revision of the literature was made regarding the stability of β-lactam antibiotics in the presence of surfactants. The factors involved in the drug decomposition were analyzed in the development of the discussion. The analysis has indicated that some organized systems obtained from surfactants can be used to control rates and mechanisms of antibiotic decomposition. These organized systems can also be used to obtain specific information about the drug reactivity in a microenvironment similar to the site of pharmacological effect.35-47engβ-lactam antibioticsDrug decompositionMicellesMicroemulsionsSurfactantsamoxicillinampicillinbeta lactam antibioticcefaclorcefadroxilcefalexincefazolincefradinecephalosporin derivativecetrimidedodecyl sulfate sodiumpenicillin derivativepenicillin Gpolidocanolpropicillinsurfactantdrug decompositiondrug hydrolysisdrug stabilitydrug structureionic strengthmicellemicroemulsionpHreviewResenhaAcesso restrito2-s2.0-00333817499114495952533044