Morais Lima, Gedson Rodrigues deFrota Machado, Flavia DannieleLucena Perico, Larissa [UNESP]Meira de Faria, FelipeLuiz-Ferreira, AndersonSouza Brito, Alba Regina MonteiroHelena Pellizzon, Cludia [UNESP]Akiko Hiruma-Lima, Claudia [UNESP]Fechine Tavares, JoseanBarbosa Filho, Jose MariaMaria Batista, Leonia2018-11-262018-11-262017-02-28World Journal Of Gastroenterology. Pleasanton: Baishideng Publishing Group Inc, v. 23, n. 8, p. 1353-1366, 2017.1007-9327http://hdl.handle.net/11449/159419AIM To evaluate the anti-inflammatory intestinal effect of the ethanolic extract (EtOHE) and hexane phase (HexP) obtained from the leaves of Combretum duarteanum (Cd). METHODS Inflammatory bowel disease was induced using trinitrobenzenesulfonic acid in acute and relapsed ulcerative colitis in rat models. Damage scores, and biochemical, histological and immunohistochemical parameters were evaluated. RESULTS Both Cd-EtOHE and Cd-HexP caused significant reductions in macroscopic lesion scores and ulcerative lesion areas. The vegetable samples inhibited myeloperoxidase increase, as well as pro-inflammatory cytokines TNF-alpha and IL-1 beta. Anti-inflammatory cytokine IL-10 also increased in animals treated with the tested plant samples. The anti-inflammatory intestinal effect is related to decreased expression of cyclooxygenase-2, proliferating cell nuclear antigen, and an increase in superoxide dismutase. CONCLUSION The data indicate anti-inflammatory intestinal activity. The effects may also involve participation of the antioxidant system and principal cytokines relating to inflammatory bowel disease.1353-1366engCombretum duarteanumMedicinal plantsCombretaceaeInflammatory bowel diseaseAnti-inflammatory intestinal activityArtigo10.3748/wjg.v23.i8.1353WOS:000395823500005Acesso abertoWOS000395823500005.pdf