Higuchi, Célio Takashi [UNESP]Pavan, Fernando Rogério [UNESP]Leite, Clarice Queico Fujimura [UNESP]Sannomiya, Miriam [UNESP]Vilegas, Wagner [UNESP]Leite, Sergio Roberto de Andrade [UNESP]Sacramento, Luis Vitor S. [UNESP]Sato, Daisy Nakamura2014-05-202014-05-202008-01-01Química Nova. Sociedade Brasileira de Química, v. 31, n. 7, p. 1719-1721, 2008.0100-4042http://hdl.handle.net/11449/26185We evaluated the potential antitubercular activity of triterpenes obtained from leaves and bark of Byrsonima crassa. From chloroform extracts of the leaves, by bioassay-guided fractionation, we obtained mixtures of known triterpenes: α-amyrin, β-amyrin and their acetates, lupeol, oleanolic acid, ursolic acid and α-amyrinone. Tested against Mycobacterium tuberculosis, the triterpenes exhibited minimum inhibitory concentrations (MICs) of 31.25 - 312.25 µg/mL. β-amyrin and friedelin, isolated from the chloroform extract of bark, showed MICs of 312.25 and 125 µg/mL respectively. This is the first report of the identification and determination of the activity of B. crassa triterpenes against M. tuberculosis.1719-1721engByrsonima crassaantitubercular activitytriterpenesArtigo10.1590/S0100-40422008000700023S0100-40422008000700023WOS:000262432800023Acesso abertoS0100-40422008000700023.pdf0000-0003-3032-2556