Oliveira, J. B AMauri, A. L. [UNESP]Petersen, C. G. [UNESP]Martins, A. M C [UNESP]Cornicelli, J.Cavagna, M.Pontes, Anaglória [UNESP]Baruffi, R. L RFranco, J. G. [UNESP]2014-05-272014-05-272006-10-01Jornal Brasileiro de Reproducao Assistida, v. 10, n. 4, p. 40-46, 2006.1517-56931518-0557http://hdl.handle.net/11449/69155The purpose of this review was to assess the efficacy of recombinant LH (r-LH) supplementation for controlled ovarian stimulation in recombinant FSH (r-FSH) and GnRH-agonist (GnRH-a) protocol for IVF/ICSI cycles. Search strategies included on-line surveys of databases from 1990 to 2006. Four trials fulfilled the inclusion criteria (Lisi et al. 2002, Humaidan et al. 2004, Marrs et al. 2004, Tarlatzis et al. 2006). When the review was carried out advantages were observed for the r-LH supplementation protocol with respect to a fewer days of stimulation, a fewer total amount of r-FSH administered and a higher serum estradiol levels on the day of hCG administration. However, these differences were not observed in number of oocyte retrieved, number of mature oocytes, clinical pregnancy per oocyte retrieval, implantation and miscarriage rates. Nevertheless, more randomized controlled trials are necessary before evidence-based recommendations regarding exogenous r-LH supplementation in ovarian stimulation protocols with r-FSH and GnRH-a for assisted reproduction treatment can be provided.40-46porGnRH agonistOvarian stimulationRecombinant FSH (r-FSH)Recombinant LH (r-LH)buserelinchorionic gonadotropinestradiolleuprorelinplaceborecombinant follitropinrecombinant luteinizing hormoneclinical trialcombination chemotherapycontrolled clinical trialdata basedose responsedrug efficacydrug mechanismestradiol blood levelfemale infertilityfertilization in vitrohormone substitutionhumanintracytoplasmic sperm injectionmedical literaturemonotherapynidationoocyte maturationovary functionrandomized controlled trialreviewspontaneous abortionArtigoAcesso aberto2-s2.0-338473096930514178654667684