Navarro, Cláudia Maria [UNESP]Sposto, Maria ReginaSgavioli Massucato, Elaine MariaAparecida Onofre, Mirian2014-05-272014-05-272004-05-01Medicina Oral, v. 9, n. 3, p. 229-233, 2004.1137-2834http://hdl.handle.net/11449/67728The authors present a case of proliferative verrucous leukoplakia (PVL) in a 78-year-old man. It was initially presented as leukoplakia on the tongue but a microscopic investigation in 1991 revealed it to be a mild epithelial dysplasia. After 5 years of follow-up, the lesion presented changes in size and location, and a recidivant behavior. In 1996, a red granular and indurated area that appeared on the tongue was found to be a microinvasive squamous cell carcinoma when microscopically investigated. After a review of the clinicopathologic behavior of this entity, the authors concluded that it was a typical PVL, whose diagnosis is difficult and retrospective, as indicated by others. The authors emphasize the importance of periodic detailed clinical and histological examination of this type of lesions in order to detect early signs of malignancy.229-233spaDysplasiaEpithelial hyperplasiaPapillomatosisProliferative verrucous leukoplakiaSquamous cell carcinomaagedcase reportclinical examinationdysplasiaepithelium hyperplasiafollow uphistologyhumanleukoplakiamalemalignant transformationmouth carcinomapapillomatosisproliferative verrucous leukoplakiareviewsquamous cell carcinomaAgedCarcinoma, Squamous CellCell Transformation, NeoplasticFollow-Up StudiesHumansLeukoplakia, OralMaleMouth NeoplasmsTime FactorsArtigoS1698-44472004000300008Acesso aberto2-s2.0-29427262812-s2.0-2942726281.pdf7650237459252010094402016106050231136068663863770000-0002-3185-2826