Silva, Acarilia EduardoOliveira, Elquio EleamenSalgado Gomes, Monique C.Marcelino, Henrique RodriguesHolanda Silva, Karen C.Souza, Bartolomeu SantosNagashima-, ToshiyukiAyala, Alejandro PedroOliveira, Anselmo Gomes de [UNESP]Tabosa do Egito, Eryvaldo Socrates2014-12-032014-12-032013-01-01Journal Of Microencapsulation. London: Informa Healthcare, v. 30, n. 8, p. 787-795, 2013.0265-2048http://hdl.handle.net/11449/113469Xylan is a biopolymer found in a variety of cell wall plants. Eudragit (R) S-100 (ES100), a pH-dependent polymer, is used as a coating material in gastroresistant delivery systems. In this study, microparticles based on both polymers were produced by interfacial cross-linking polymerisation and/or spray-drying technique in order to investigate feasibility and stability of the systems. Size and morphology of the microparticles were characterised by optical and SEM while FT-IR, thermal analysis (TG/DTA), and X-ray diffraction (XRD) evaluated the drug-polymer interactions and the thermal behaviour of the systems. FT-IR confirmed the absence of chemical interaction between the polymers. TG/DTA analysis showed a higher stability for spray-dried microparticles and XRD data proved the amorphous feature of both carriers. The results reveal that xylan/ES100 microparticles can be produced by chemical or physico-mechanical ways, the latter being the best option due to the lack of toxic cross-linking agents and easy scale-up.787-795engCross-linkinginfrared spectroscopypolymer-biopolymer interactionspray-dryingthermal analysisArtigo10.3109/02652048.2013.788087WOS:000326194600008Acesso restrito9114495952533044