Flausino, OtavioSantos, Luciana de AvilaVerli, HugoPereira, Ana MariaBolzani, Vanderlan da Silva [UNESP]Nunes-de-Souza, Ricardo Luiz2014-05-202014-05-202007-01-01Journal of Natural Products. Washington: Amer Chemical Soc, v. 70, n. 1, p. 48-53, 2007.0163-3864http://hdl.handle.net/11449/34065One new erythrinian alkaloid derivative, (+)-11 alpha-hydroxyerythravine (1), and the known (+)-erythravine (2) and (+)-alpha-hydroxyerysotrine (3) were isolated from the flowers of Erythrina mulungu. Their structures were determined by spectroscopic/spectrometric data interpretation of H-1, C-13, and 2D NMR and MS experiments. The relative configuration was established by NOESY analysis, while the conformation adopted by these molecules was evaluated through molecular modeling studies and coupling constants obtained by NMR analysis. Furthermore, the anxiolytic effects of the E. mulungu aqueous alcoholic crude extract and of the purified alkaloids were evaluated using the elevated T-maze test.48-53engArtigo10.1021/np060254jWOS:000243734900011Acesso restrito4484083685251673