De Morales, Rogério RizoMorales, Nivea de Macedo OliveiraRocha, Fernando Coronetti Gomes da [UNESP]Fenelon, Sheila BernardinoPinto, Rogério de Melo CostaDa Silva, Carlos Henrique Martins2014-05-272014-05-272007-06-01Arquivos de Neuro-Psiquiatria, v. 65, n. 2 B, p. 454-460, 2007.0004-282X1678-4227http://hdl.handle.net/11449/69685Multiple sclerosis (MS) is a chronic disease which may exert significant effects on the life of patients. Traditional outcome measures in MS lack in consider the effects of the disease on health-related quality of life (HRQoL). The goal of this study is to measure HRQoL in MS patients in the city of Uberlân-dia, State of Minas Gerais, Brazil. The Brazilian version of the SF-36 was applied in 23 MS patients and in 69 subjects of general population (blood donors) in Uberlândia. MS patients scored lower in all SF-36 scales than do the general population, principally in physical function domains. Patients with EDSS scores ≤3.5 had higher mean scores in four domains than do the patients with EDSS scores ≥4.0, and lower in all domains than control group. Depressive symptoms and heat intolerance showed correlation with SF-36 domains and components. In conclusion, MS patients have a significant negative impact on all HRQoL domains measured by SF-36, compared with general population, even in the stages with lower disability.454-460porHealth evaluationMultiple sclerosisQuality of lifeadultBrazilclinical articlecontrolled studycorrelation analysisdepressiondisabilityfemalefunctional assessmentheat intolerancehumanmalemultiple sclerosisoutcome assessmentquality of liferating scalescoring systemShort Form 36AdolescentAdultCase-Control StudiesCross-Sectional StudiesDisability EvaluationFemaleHealth StatusHumansMaleMiddle AgedMultiple SclerosisQuality of LifeQuestionnairesSeverity of Illness IndexSickness Impact ProfileArtigo10.1590/S0004-282X2007000300018S0004-282X2007000300018WOS:000248225000018Acesso aberto2-s2.0-345476146102-s2.0-34547614610.pdf4044986284615753