dos Santos, Marcelo L.Fagundes, Fabio H. R.Teixeira, Bruno R. F.Toyama, Marcos H. [UNESP]Aparicio, Ricardo2014-05-202014-05-202008-05-01International Journal of Molecular Sciences. Basel: Mdpi Ag, v. 9, n. 5, p. 736-750, 2008.1661-6596http://hdl.handle.net/11449/397BjVIII is a new myotoxic Lys49-PLA2 isolated from Bothrops jararacussu venom that exhibits atypical effects on human platelet aggregation. To better understand the mode of action of BjVIII, crystallographic studies were initiated. Two crystal forms were obtained, both containing two molecules in the asymmetric unit (ASU). Synchrotron radiation diffraction data were collected to 2.0 angstrom resolution and 1.9 angstrom resolution for crystals belonging to the space group P2(1)2(1)2(1) (a = 48.4 angstrom, b = 65.3 angstrom, c = 84.3 angstrom) and space group P3(1)21 (a = b = 55.7 angstrom, c = 127.9 angstrom), respectively. Refinement is currently in progress and the refined structures are expected to shed light on the unusual platelet aggregation activity observed for BjVIII.736-750engLys49-PLA2Bothrops jararacussuplatelet aggregationphospholipase crystallographic analysisArtigo10.3390/ijms9050736WOS:000256308000004Acesso abertoWOS000256308000004.pdf