Jakubovski, EwgeniPittenger, ChristopherTorres, Albina Rodrigues [UNESP]Fontenelle, Leonardo Franklindo Rosario, Maria ConceicaoFerrão, Ygor Arzenode Mathis, Maria AliceMiguel, Euripedes ConstantinoBloch, Michael H.2014-05-272014-05-272011-08-15Progress in Neuro-Psychopharmacology and Biological Psychiatry, v. 35, n. 7, p. 1677-1681, 2011.0278-58461878-4216http://hdl.handle.net/11449/72605Background: Cross-sectional studies have associated poor insight in patients with obsessive-compulsive disorder (OCD) with increased OCD symptom severity, earlier age of onset, comorbid depression, and treatment response. The goal of this current study was to examine the relationship between dimensions of OCD symptomatology and insight in a large clinical cohort of Brazilian patients with OCD. We hypothesized that poor insight would be associated with total symptom severity as well as with hoarding symptoms severity, specifically. Methods: 824 outpatients underwent a detailed clinical assessment for OCD, including the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), the Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS), the Brown Assessment of Beliefs Scale (BABS), a socio-demographic questionnaire, and the Structured Clinical Interview for axis I DSM-IV disorders (SCID-P). Tobit regression models were used to examine the association between level of insight and clinical variables of interest. Results: Increased severity of current and worst-ever hoarding symptoms and higher rate of unemployment were associated with poor insight in OCD after controlling for current OCD severity, age and gender. Poor insight was also correlated with increased severity of current OCD symptoms. Conclusion: Hoarding and overall OCD severity were significantly but weakly associated with level of insight in OCD patients. Further studies should examine insight as a moderator and mediator of treatment response in OCD in both behavioral therapy and pharmacological trials. Behavioral techniques aimed at enhancing insight may be potentially beneficial in OCD, especially among patients with hoarding. © 2011.1677-1681engHoardingInsightObsessive-compulsive disorderSymptom dimensionadultage distributionBrown Assessment of Belief Scalechildclinical assessment toolcomorbiditycontrolled studydepressiondimensional yale brown obsessive compulsive scaledisease durationdisease severityemployment statusfemalehumanintrospectionmajor clinical studymalemarriageobsessive compulsive disorderonset agepreschool childquestionnaireschool childsex differenceStructured Clinical Interview for DSM Disorderssymptomatologytreatment responseunemploymentYale Brown Obsessive Compulsive ScaleAdultBrazilCohort StudiesDelusionsDisease ProgressionFemaleHumansMaleMiddle AgedObsessive HoardingObsessive-Compulsive DisorderPerceptionPsychiatric Status Rating ScalesQuestionnairesTime FactorsYoung AdultArtigo10.1016/j.pnpbp.2011.05.012Acesso restrito2-s2.0-799611271043837157956819433