Fernandes, Daniara Cristina [UNESP]Regasini, Luis Octávio [UNESP]Vellosa, José Carlos Rebuglio [UNESP]Pauletti, Patrícia Mendonça [UNESP]Castro-Gamboa, Ian [UNESP]Bolzani, Vanderlan da Silva [UNESP]Oliveira, Olga Maria Mascarenhas [UNESP]Silva, Dulce Helena Siqueira [UNESP]2014-05-272014-05-272008-05-19Chemical and Pharmaceutical Bulletin, v. 56, n. 5, p. 723-726, 2008.0009-23631347-5223http://hdl.handle.net/11449/70410Two new flavone glucosides, nitensosides A and B (1, 2), together with four known compounds, sorbifolin (3), sorbifolin 6-O-β-glucopyranoside (4), pedalitin (5), and pedalitin 6-O-β-glucopyranoside (6) were isolated from Pterogyne nitens. Their structures were elucidated from 1D and 2D NMR analysis, as well as by high resolution mass spectrometry. All the isolated flavones were evaluated for their myeloperoxidase (MPO) inhibitory activity. The most active compound, pedalitin, exhibited IC 50 value of 3.75 nM on MPO. Additionally, the radical-scavenging capacity of flavones 1-6 was evaluated towards ABTS and DPPH radicals and compared to standard compounds quercetin and Trolox®. © 2008 Pharmaceutical Society of Japan.723-726engAntioxidantFlavoneMyeloperoxidasePterogyne nitensRadical scavengingflavone derivativeglucosidemyeloperoxidasenitensoside anitensoside bpedalitinpedalitin 6 o beta glucopyranosidesorbifolinsorbifolin 6 o beta glucopyranosidecontrolled studydrug inhibitiondrug structureIC 50legumenonhumannuclear magnetic resonanceBenzothiazolesEnzyme InhibitorsFabaceaeFlavonesFree Radical ScavengersGlucosidesMagnetic Resonance SpectroscopyPeroxidasePicratesPlant LeavesSulfonic AcidsArtigo10.1248/cpb.56.723WOS:000256184200021Acesso aberto2-s2.0-434491101384484083685251673470200490423124809927364527645500000-0002-1516-7765