Canto, G. S.Dalmora, S. L.Oliveira, Anselmo Gomes de [UNESP]2014-05-202014-05-201999-01-01Drug Development and Industrial Pharmacy. New York: Marcel Dekker Inc., v. 25, n. 12, p. 1235-1239, 1999.0363-9045http://hdl.handle.net/11449/7694Liposomes of soya phosphatidylcholine, cholesterol, and stearylamine (molar ratio 6/3/1) and 0.1% alpha-tocopherol were prepared by the extrusion of multilamellar vesicles through 0.2-mu m polycarbonate membrane. Liposomes were characterized by electron transmission microscopy, and the mean structure diameter was 278 nm. The encapsulation efficiency obtained was 12.73%. The topical anti-inflammatory effect was evaluated in vivo by the cotton pellet granuloma method. We analyzed free piroxicam at 4 mg/kg, piroxicam encapsulated in liposomes added to 1.5% hydroxyethylcellulose (HEC) gel at 1.6 mg/kg, and piroxicam encapsulated in liposomes added to HEC gel at 4 mg/kg; the inhibition of inflammation obtained was 21.1%, 32.8%, and 47.4%, respectively. These results showed that the encapsulation of piroxicam produced an increase of topical anti-inflammatory effect, suggesting that the inhibition of inflammation can be obtained with lower drug concentrations.1235-1239engArtigo10.1081/DDC-100102293WOS:000084610500002Acesso restrito9114495952533044