Melo, Fernando L.Benati, Fabricio J.Roman, Walter Antonio [UNESP]Palazzo de Mello, Joao CarlosNozawa, CarlosCarvalho Linhares, Rosa Elisa2014-05-202014-05-202008-01-01Microbiological Research. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 163, n. 2, p. 136-139, 2008.0944-5013http://hdl.handle.net/11449/42556We investigated the antiviral activity of an aliphatic nitro compound (NC) isolated from Heteropteris aphrodisiaca O. Mach. (Malpighiaceae), a Brazilian medicinal ptant. The NC was tested for its antiviral activity against poliovirus type 1 (PV-1) and bovine herpes virus type 1 (BHV-1) by plaque reduction assay in cell culture. The NC showed a moderate antiviral activity against PV-1 and BHV-1 in HEp-2 celts, and the 50% inhibitory concentration (IC50) were 22.01 mu g/ml (selectivity index (SI) = 2.83) and 21.10 mu g/mi (SI = 2.95), respectivety. At the highest concentration of the drug (40 mu g/ml) a reduction of approximately 80% in plaque assay was observed for both viruses. The treatment of cells or virus prior to infection did not inhibit the replication of virus strains. (C) 2006 Elsevier GmbH. All rights reserved.136-139engHeteropteris ophrodisiacaaliphatic nitro compoundpoliovirusantiviral activitybovine herpesvirusArtigo10.1016/j.micres.2006.03.011WOS:000254531400003Acesso abertoWOS000254531400003.pdf