Luchini, Ana Carolina [UNESP]Costa de Oliveira, Deborah Mara [UNESP]Pellizzon, Claudia Helena [UNESP]Di Stasi, Luiz Claudio [UNESP]Gomes, Jose Carlos [UNESP]2014-05-202014-05-202009-01-01Mediators of Inflammation. New York: Hindawi Publishing Corporation, p. 7, 2009.0962-9351http://hdl.handle.net/11449/17510The present study aimed to clarify the role of mast cells in colitis with relapse induced in Wistar rats by trinitrobenzenosulphonic acid. Colitis induction increased the histamine concentration in the colon, which peaked on day 26. The number of mast cells, probably immature, was ten times higher on day 8. Different from animals infected with intestinal parasites, after colitis remission, mast cells do not migrate to the spleen, showing that mast cell proliferation presents different characteristics depending on the inflammation stimuli. Treatment with sulfasalazine, doxantrazole, quercetin, or nedocromil did not increase the histamine concentration or the mast cell number in the colon on day 26, thereby showing absence of degranulation of these cells. In conclusion, although mast cell proliferation is associated with colitis, these cells and their mediators appear to play no clear role in the colitis with relapses. Copyright (C) 2009 Ana Carolina Luchini et al.7engArtigo10.1155/2009/432493WOS:000266378000001Acesso abertoWOS000266378000001.pdf001939377980106916975473250964570000-0002-4494-4180