Cavalli, L. R.Cavaliéri, L. M BRibeiro, L. A. [UNESP]Cavalli, I. J.Silveira, R.Rogatto, Silvia Regina [UNESP]2014-05-272014-05-271997-11-03Hereditas, v. 126, n. 3, p. 261-268, 1997.0018-0661http://hdl.handle.net/11449/65224Chromosome analysis was performed on samples from 20 Brazilian patients with breast cancer. All the samples were from untreated patients who presented the clinical symptoms for months or years before surgical intervention. Six cases showed axillary lymph node metastases. Clonal chromosome abnormalities were detected in all cases. The numerical alterations most frequently observed involved the loss of chromosomes X, 19, 20, and 22 followed by gain of chromosomes 9 and 8. Among the structural anomalies observed, there was preferential involvement of chromosomes 11, 6, 1, 7, 3, and 12, supporting previous reports that these chromosomes may harbour genes of importance in the development of breast tumors. Two cases with a family history of breast cancer had in common total or partial trisomy 1.261-268engaxillary lymph nodebrazilbreast cancerchromosome 1chromosome 11chromosome 12chromosome 19chromosome 20chromosome 22chromosome 3chromosome 6chromosome 7chromosome 8chromosome 9clinical articlecytogeneticsfemalehumanlymph node metastasismalenumerical chromosome aberrationpartial trisomystructural chromosome aberrationX chromosomeAdultAgedAged, 80 and overBrazilBreast NeoplasmsBreast Neoplasms, MaleCarcinoma, Ductal, BreastChromosome AberrationsChromosome DisordersChromosome MappingChromosomes, HumanFemaleHumansKaryotypingLymphatic MetastasisMaleMiddle AgedNeoplasmsTrisomyX ChromosomeArtigo10.1111/j.1601-5223.1997.00261.xAcesso aberto2-s2.0-00306565202-s2.0-0030656520.pdf