Coelho, Roberta GomesHonda, Neli KikaVieira, Maria do CarmoBrum, Rosenei LouzadaPavan, Fernando Rogério [UNESP]Leite, Clarice Queico Fujimura [UNESP]Lima Cardoso, Claudia Andrea2014-05-202014-05-202010-10-01Journal of Medicinal Food. New Rochelle: Mary Ann Liebert Inc., v. 13, n. 5, p. 1277-1280, 2010.1096-620Xhttp://hdl.handle.net/11449/7417Bromelia balansae (Family Bromeliaceae) is a medicinal plant commonly used in the central region of Brazil as a cough syrup and also eaten roasted. The methanolic extract of ripe fruits was analyzed by chromatographic methods and spectrometrically. Four glycoside flavonols were isolated: kaempferol-3-O-alpha-l-rhamnopyranoside (1), kaempferol-3-O-alpha-L-rhamnopyranosyl-(1 -> 6)-beta-d-glucopyranoside (2), quercetin-3-O-alpha-L-rhamnopyranosyl-(1 -> 6)-beta-D-glucopyranoside (3), and kaempferol 3,7-di-O-alpha-L-rhamnopyranoside (4). The resazurin microtiter assay was used to measure the biological activity in vitro against Mycobacterium tuberculosis. The results showed a moderate activity of the methanolic extract with a minimal inhibitory concentration of 128 mu g/mL. Antioxidant activity was evaluated as free radical scavenging capacity and inhibition of peroxidation. Free radical scavenging capacity was assessed by measuring the scavenging activity of methanolic extract and methanolic fraction on 2,2-diphenyl-1-picrylhydrazyl radical. The methanolic extract showed low values of antioxidant activities, whereas the methanolic fraction exhibited free radical scavenging activity ranging from 20.2% to 91.1%, and the inhibition of peroxidation values ranging from 5.6% to 27.5%. This is the first chemical study reported in the literature about this species.1277-1280engantioxidant activityantituberculosis activityBromelia balansaeBromeliaceaecaraguata''flavonolsgravata''Mycobacterium tuberculosisArtigo10.1089/jmf.2009.0032WOS:000282365600035Acesso restritoWOS000282365600035.pdf2114570774349859