da Silva, Carla CristianeKurokawa, Cilmery Suemi [UNESP]Nga, Hong SiMoretto, Maria Regina [UNESP]Dalmas, Jose CarlosGoldberg, Tamara Beres Lederer [UNESP]2014-05-202014-05-202012-06-01Journal of Pediatric Endocrinology & Metabolism. Berlin: Walter de Gruyter & Co, v. 25, n. 5-6, p. 479-484, 2012.0334-018Xhttp://hdl.handle.net/11449/13172Eighty-seven male volunteers were grouped according to bone age (BA): 10-12 years (n=25), 13-15 years (n=36), and 16-18 years (n=26), and the following were recorded for each: weight (kg), height (m), BMI (kg/m(2)), calcium intake from three 24-h food recalls (mg/day), puberty evaluation by Tanner stages, bone biomarker (BB) evaluation, serum osteocalcin (OC), bone alkaline phosphatase (BAP), carboxyterminal telopeptide (S-CTx), and bone mineral density (BMD) evaluations by dual-energy X-ray absorptiometry (g.cm(2)) in the lumbar spine, proximal femur, and the whole body. BBs showed similar behaviors, and very high median values were observed for individuals aged 13-15 years (BAP=155.50 IU/L, OC=41.63 ng/mL, S-CTx=2.09 ng/mL). Lower median BB values were observed with advancing BA between 16 and 18 years (BAP=79.80 IU/L, OC=27.80 ng/mL, S-CTx=1.65 ng/mL). Stepwise multiple regression analysis showed body weight associated with BA as independent variables with greater determination power for S-CTx (r(2)=0.40) and OC (r(2)=0.21). For BAP, stepwise analysis showed body weight and whole-body BMD (r(2)=0.34). All predictive models showed significance (p<0.01). A high turnover for both bone formation and resorption biomarkers, particularly from 13 to 15 years of BA, were observed along with very low values in the 16-18 age range. Weight and BA were significant in determining predictive equations of OC and of S-CTx, whereas for BAP, weight and BMD of full body were selected.479-484engbone agebone biomarkersbone mineral densityBrazilian adolescentspubertal stagesArtigo10.1515/jpem-2012-0022WOS:000309754800013Acesso restrito851042326954046572148348592603970000-0001-7017-766X0000-0003-1380-7527