Pontillo, AlessandraReis, Edione C.Bricher, Pamela N.Vianna, PriscilaDiniz, SolangeFernandes, Karla S.Chies, José A.Sandrim, Valeria [UNESP]2015-10-212015-10-212015-06-01American Journal Of Reproductive Immunology. Hoboken: Wiley-blackwell, v. 73, n. 6, p. 577-581, 2015.1046-7408http://hdl.handle.net/11449/128571Problem: Augmented levels of IL-1 ss have been pointed out as an important pathogenic factor for preeclampsia development. Inflammasome is the cytoplasmic complex responsible for pro-IL1 ss cleavage and IL-1 ss secretion. Aim of the study was to evaluate the association between polymorphisms in inflammasome'genes and preeclampsia. Method of study: Selected polymorphisms in inflammasome genes (NLRP1, NLRP3, CARD8, and IL1B) were analyzed in 286 Brazilian women with and 309 without preeclampsia. Results and Conlclusions: The NLRP1 variant rs12150220 (L155H) was associated with the development of preeclampsia (OR=1.58), suggesting a role of this inflammasome receptor in the pathogenesis of this multifactorial disorder.577-581engIL-1 ssInflammasomeNLRP1PreeclampsiaArtigo10.1111/aji.12353WOS:000354390000010Acesso restrito