Borges, Mirela B. [UNESP]Montenegro, Mário R. [UNESP]Lima, Jussara L. [UNESP]Matsubara, Luiz Shiguero [UNESP]Zornoff, Leonardo Antonio Mamede [UNESP]Moura, Regina [UNESP]Okoshi, Marina Politi [UNESP]2014-05-272014-05-271999-11-01Revista Brasileira de Medicina, v. 56, n. 11, p. 1147-1152, 1999.0034-7264http://hdl.handle.net/11449/65883Castleman's disease (CD) is an uncommon lymphoproliferative disorder that is morphologically and clinically heterogeneous. Both a localized benign variant and a multicentric form with systemic manifestations have been described. Although there are many published cases in literature, there are a few reports about this pathology in Brazil. We describe a patient with several manifestations of multicentric CD: lymphadenopathy, weight loss, fever, arthralgia, myalgia, and hepatosplenomegaly. Pathological examination of excised cervical lymph node revealed its rarest form: a CD of the hyaline-vascular type in multicentric presentation.1147-1152porAngiofollicular lymph node hyperplasiaHepatosplenomegalyLymphadenopathyArtigoAcesso aberto2-s2.0-5844321368630983513799876644631386719984325016839015394547