Chapla, Vanessa Mara [UNESP]Zeraik, Maria Luiza [UNESP]Ximenes, Valdecir F. [UNESP]Zanardi, Lisineia Maria [UNESP]Lopes, Márcia Nasser [UNESP]Cavalheiro, Alberto José [UNESP]Silva, Dulce Helena Siqueira [UNESP]Young, Maria Claudia M.Fonseca, Luiz Marcos da [UNESP]Bolzani, Vanderlan da Silva [UNESP]Araújo, Angela Regina [UNESP]2014-12-032014-12-032014-05-01Molecules. Basel: Mdpi Ag, v. 19, n. 5, p. 6597-6608, 2014.1420-3049http://hdl.handle.net/11449/113198Chemical investigation of an acetonitrile fraction from the endophytic fungus Phomopsis sp. led to the isolation of the new natural product 2-hydroxy-alternariol (7) together with the known compounds cytochalasins J (1) and H (2), 5'-epialtenuene (3) and the mycotoxins alternariol monomethyl ether (AME, 4), alternariol (AOH, 5) and cytosporone C (6). The structure of the new compound was elucidated by using 1-D and 2-D NMR (nuclear magnetic resonance) and high resolution mass spectrometry. The cytochalasins J (1) and H (2) and AOH (5) exhibited potent inhibition of the total ROS (reactive oxygen species) produced by stimulated human neutrophils and acted as potent potential anti-inflammatory agents. Moreover, cytochalasin H (2) demonstrated antifungal and acetylcholinesterase enzyme (AChE) inhibition in vitro.6597-6608engsecondary metabolitesbioactivitiesendophytic fungiPhomopsis sp.Senna spectabilisArtigo10.3390/molecules19056597WOS:000337113000070Acesso abertoWOS000337113000070.pdf47020049042312480000-0001-7616-96520000-0002-1516-7765