Duque, C.Hebling, J.Smith, A. J.Giro, EMAOliveira, M. F.Costa, CAD2014-05-202014-05-202006-06-01Journal of Oral Rehabilitation. Oxford: Blackwell Publishing, v. 33, n. 6, p. 452-461, 2006.0305-182Xhttp://hdl.handle.net/11449/32887Objective: the aim of this in vivo study was to evaluate the response of the pulp-dentin complex following application of resin-modified glass-ionomer cement, calcium hydroxide hard-setting cement and EDTA-soluble preparation of dentine matrix proteins (ESDP) in deep cavities prepared in non-human primate teeth. Methods: Eighteen deep Class V buccal cavities were prepared in premolars of four capuccin monkeys. In Groups 1 and 2, the cavity floor was lined with ESDP or a resin-modified glass-ionomer cement (Vitrebond - 3M ESPE), respectively. In Group 3 (control), the cavity was lined with a hard setting calcium hydroxide cement (Dycal - Dentsply). The cavities were subsequently filled with amalgam. After 6 months, the animals were sacrificed and the teeth were prepared for microscopic assessment. Six-micron thick serial sections were stained with H/E, Masson's trichrome and Brown & Brenn techniques. Results: No inflammatory pulpal response was observed for all experimental and control Groups. However, the amount of reactionary dentin deposition differed between groups in the rank order ESDP (Group 1) > calcium hydroxide (Group 3) > resin-modified glass-ionomer (Group 2). These differences were statistically significant. Conclusions: All materials were biocompatible when applied in deep cavities. ESDP stimulated higher deposition of reactionary dentin matrix than Vitrebond and Dycal.452-461engpulpdentinebioactive moleculesdental materialslinersdental cavitiesArtigo10.1111/j.1365-2842.2005.01585.xWOS:000237298900010Acesso restrito009703168206365256518745094936170000-0002-2575-279X