Pereira, Ticiana PracianoCampos, Adriana RolimLeal, Luzia Kalyne A. M.Pierdona, Taiana MagalhaesToyama, Marcos H. [UNESP]Azul Monteiro, Helena SerraCosta Martins, Alice Maria2014-05-202014-05-202010-07-01Natural Product Communications. Westerville: Natural Products Inc, v. 5, n. 7, p. 1103-1106, 2010.1934-578Xhttp://hdl.handle.net/11449/40506The effect was investigated of the K+ channel blocker, glibenclamide, on the ability of Crotalus durissus cumanensis venom (CDCM) to promote peripheral antinociception. This was measured by formalin-induced nociception in male Swiss mice. CDCM (200 and 300 mu g/kg) produced an antinociceptive effect during phase 2 in the formalin test. The effect of CDCM (200 mu g/kg) was unaffected by the ATP-sensitive K+ channel blocker glibenclamide (2 mg/kg). These results suggest that CDCM is effective against acute pain. However, the ATP-sensitive K+ channels pathway is not contributable to the antinoeiceptive mechanism of CDCM.1103-1106engCrotalus durissus cumanensis venomnociceptionglibenclamideArtigoWOS:000280117300025Acesso restrito