Verona, Carlos BeneditoZerati Filho, Miguel [UNESP]El Ammar Müller, MárcioAlmeida Calado, Adriano2014-05-272014-05-272004-04-01Revista Brasileira de Medicina, v. 61, n. 4, p. 222-227, 2004.0034-7264http://hdl.handle.net/11449/67702The renal cell carcinoma (RCC) is the seventh most common malignancy, accounting for more than 3% of cancer incidence in the United States. RCC is more common in males, occurring primarily in the 5 th to 7 th decades of life. At the time of presentation one third of the patients have advanced disease and about 50% of the patients that underwent radical nephrectomy have recurrence. With the mainstream implementation of imaging modalities, such as ultrasound, the incidental detection of RCC has dramatically increased in recent years. Patients with metastatic RCC without treatment have na average survival of 6 to 10 months, and only 10 to 20% can be expected to survive 2 years. Treatment for patients with advanced disease remains unsatisfactory and the metastatic renal cancer continue to present a therapeutic challenge systemic therapies employed in patients with this tumor include chemotherapy, hormonal therapy, and immunotherapy. The authors review the treatment strategies of the metastatic renal cell carcinoma (RCC).222-227porImunotherapyMetastasisRenal cell carcinomaTreatmentalpha interferoninterleukin 2age distributioncancer chemotherapycancer combination chemotherapycancer hormone therapycancer immunotherapycancer incidencecancer radiotherapycancer survivalclinical trialechographyhumanimagingincidental findingkidney carcinomametastasisnephrectomyreviewsex differenceUnited StatesArtigoAcesso aberto2-s2.0-2942527338