Melo, Nathalie Ferreira Silva de [UNESP]Grillo, Renato [UNESP]Rosa, André Henrique [UNESP]Fraceto, Leonardo Fernandes [UNESP]Dias Filho, Newton Luiz [UNESP]Paula, Eneida deAraújo, Daniele Ribeiro de2014-05-202014-05-202010-01-01Química Nova. Sociedade Brasileira de Química, v. 33, n. 1, p. 65-69, 2010.0100-4042http://hdl.handle.net/11449/156In this paper we describe the preparation poly (L-lactide) (PLA) nanocapsules as a drug delivery system for the local anesthetic benzocaine. The characterization and in vitro release properties of the system were investigated. The characterization results showed a polydispersity index of 0.14, an average diameter of 190.1± 3 nm, zeta potential of -38.5 mV and an entrapment efficiency of 73%. The release profile of Benzocaine loaded in PLA nanocapsules showed a significant different behavior than that of the pure anesthetic in solution. This study is important to characterize a drug release system using benzocaine for application in pain treatment.65-69porlocal anesthesicPLA nanocapsulesdrug releaseArtigo10.1590/S0100-40422010000100013S0100-40422010000100013WOS:000274726800013Acesso abertoS0100-40422010000100013.pdf150948051504657221887368857212420000-0002-2042-018X0000-0002-0284-5782