de Castro, Mateus V.Silva, Monize V. R.Naslavsky, Michel S.Scliar, Marilia O.Nunes, KellyPassos-Bueno, Maria RitaCastelli, Erick C. [UNESP]Magawa, Jhosiene Y.Adami, Flávia L.Moretti, Ana I. S.de Oliveira, Vivian L.Boscardin, Silvia B.Cunha-Neto, EdecioKalil, JorgeJouanguy, EmmanuelleBastard, PaulCasanova, Jean-LaurentQuiñones-Vega, MauricioSosa-Acosta, Patriciade Guedes, Jéssica S.de Almeida, Natália P.Nogueira, Fábio C. S.Domont, Gilberto B.Santos, Keity S.Zatz, Mayana2023-07-292023-07-292022-12-01Immunity and Ageing, v. 19, n. 1, 2022.1742-4933http://hdl.handle.net/11449/249002Background: Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied three Brazilian supercentenarians, older than 110 years, who survived Covid-19 in 2020 before being vaccinated. Results: Despite their advanced age, humoral immune response analysis showed that these individuals displayed robust levels of IgG and neutralizing antibodies (NAbs) against SARS-CoV-2. Enrichment of plasma proteins and metabolites related to innate immune response and host defense was also observed. None presented autoantibodies (auto-Abs) to type I interferon (IFN). Furthermore, these supercentenarians do not carry rare variants in genes underlying the known inborn errors of immunity, including particular inborn errors of type I IFN. Conclusion: These observations suggest that their Covid-19 resilience might be a combination of their genetic background and their innate and adaptive immunity.engCovid-19ElderlySARS-CoV-2SupercentenariansArtigo10.1186/s12979-022-00310-y2-s2.0-85142189171