Moro, Antonio C. [UNESP]Mauro, Antonio Eduardo [UNESP]Netto, Adelino Vieira de Godoy [UNESP]Ananias, Sandra R. [UNESP]Quilles, Marcela B. [UNESP]Carlos, Iracilda Z. [UNESP]Pavan, Fernando R. [UNESP]Leite, Clarice Q. F. [UNESP]Hoerner, Manfredo2014-05-202014-05-202009-11-01European Journal of Medicinal Chemistry. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 44, n. 11, p. 4611-4615, 2009.0223-5234http://hdl.handle.net/11449/7324The reactions between [Pd(C-2,N-dmba)(mu-X)](2) (dmba = N,N-dimethylbenzylamine: X = Cl, Br) and thiourea (tu) in the 1:2 molar ratio at room temperature resulted in the mononuclear compounds [Pd(C-2,N-dmba)(Cl)(tu)] (1) and [Pd(C-2,N-dmba)(Br)(tu)] (2), which were characterized by elemental analyses and infrared (IR), H-1- and C-13{H-1} NMR spectroscopies. The crystal and molecular structures of 2 were determined by single-crystal X-ray diffraction. In vitro cytotoxicity assays of the compounds 1, 2, tu, dmba and cisplatin were carried out using two murine tumor cell lines, namely mammary adenocarcinoma (LM3) and lung adenocarcinoma (LP07). The compounds 1, 2, tu and dmba were also tested against Mycobacterium tuberculosis and their MIC values were determined. (C) 2009 Elsevier Masson SAS. All rights reserved.4611-4615engCyclopalladated complexCrystal structurecytotoxicity assaysMycobacterium tuberculosisAntitumorThioureaArtigo10.1016/j.ejmech.2009.06.032WOS:000271225800041Acesso restrito330022397081444879276770536508190000-0002-0057-7964